Human Islet miR-199a-5p and miR-214-3p Associate With Donor Age, BMI, and Sex and Mediate Cellular Aging in Islet-Derived Cells.

Acta Physiol (Oxf) · 2026 · PMC13401865 · PMID 42502989

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highly significantno p-value reported

A highly significant inhibition (between 32% and 100%) for both these microRNAs was maintained within these cells from different donors during multiple replication cycles in vitro.

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a significant trendno p-value reported

When grouped by decades of age, a significant trend was observed for miR‐199a‐5p and miR‐214‐3p (Figure 2B,C ; trend p ‐values 0.0384 and 0.0314, respectively).

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