CD96 marks a phenotypically distinct checkpoint-associated HCV-specific CD8+ T-cell subset featuring memory-associated states.

For the TIGIT+ cells, there was also a clear trend toward decrease after eradication, but it did not reach statistical significance (72,78% vs. 43,43%, p=0,0625).

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Moreover, in the HCV-specific subset, the MFI showed a statistical trend toward increased levels in the chronic group compared to the other groups ( Figure 2D ), with a significantly higher MFI of CD96 in cHCV patients compared to the rHCV patients (1882,33 vs. 1001,29, p=0,0130).

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