Mycobacterium tuberculosis IDH-PPARγ interaction suppresses GPX4 to drive macrophage ferroptosis and sustain persistent infection.

Nat Commun · 2026 · PMC13402603 · PMID 42259813

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Additionally, serum levels of malondialdehyde (MDA), a marker of lipid peroxidation, increased after infection and showed a trend toward reduction following PPARγ knockout, although this change was not statistically significant (Supplementary Fig. 7h ).

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