GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy.

Prior to pleiotropy test, analysis of genetic correlation between the traits showed a highly significant genetic correlation between t-tau and p-tau181 ( p = 6.99 × 10 −303 ), however, correlation of these two traits with Aβ42 was not significant (p Aβ42 vs t-tau = 0.25 and p Aβ42 vs p-tau181 = 0.27).

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Circulating HDL levels are reported to be associated with decreased AD risk, and we observed nominally significant and positive covariance with CSF Aβ42 (r g- =0.007, SE = 0.003, p = 1.96×10 −02 ) in our analysis, although this failed to pass the FDR-corrected significance threshold.

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