Barely Significant
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Public Discourse on Menopausal Skin Management: A YouTube Infodemiology Study of Treatment Perceptions, Sentiment, and Unmet Needs Across 43 954 Viewer Comments

J Cosmet Dermatol · 2026 · PMC13403088

Europe PMC
1
hedged sentence
0.1260
closest p · 2.5× alpha
0.1260
boldest claim

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did not reach statistical significancep = 0.126not close (p > 0.1)
An exploratory pre/post comparison around the FDA's November 2025 HRT boxed warning removal showed a numerically higher proportion of positive HRT comments in the post‐announcement period (53.1% positive, 29.2% negative, n = 1379) compared with the pre‐announcement period (50.5% positive, 30.5% negative, n = 4575), but this difference did not reach statistical significance ( p = 0.126) over the 4.5‐month post‐announcement window available in this dataset. 3.6.

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