Age-stratified prognostic performance of hematologic inflammatory indices for 30-day mortality in emergency department patients with PCR-confirmed COVID-19: A cohort study from the pre-vaccination pandemic era.

Formal DeLong testing for independent ROC curves confirmed that the age-related attenuation in discriminatory performance was statistically significant for SII (AUC < 65: 0.727 vs ≥ 65: 0.570; ΔAUC = 0.159; Z = 2.776; P = 0.0055), whereas for SIRI (ΔAUC = 0.072; Z = 1.201; P = 0.230) and PIV (ΔAUC = 0.089; Z = 1.499; P = 0.134), the AUC differences did not reach statistical significance, although the directional patterns were consistent with that observed for SII.

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Model 2 (Demographics + Comorbidities): After adjusting for age, sex, and all comorbidities, age ≥ 65 years (aOR 6.84, 95% CI: 4.72–9.92, p < 0.001) remained highly significant, though its effect was partially attenuated.

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