Selective GPR17 antagonism enhances structural and functional recovery in animal models of demyelination.

Although this difference did not reach statistical significance, the direction of the effect, together with the heterogeneous nature of demyelination in the cuprizone model, suggests that these findings are more likely reflective of partial or incomplete myelin loss rather than a complete absence of structural pathology, as well as linked to the small sample size included in EM-analyses.

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