Therapeutic role of semaglutide in metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis: A systematic review and meta-analysis of placebo-controlled trials with GRADE evidence assessment.

Medicine (Baltimore) · 2026 · PMC13406235 · PMID 42499082

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

a strong trendP = .06so close (0.05 < p ≤ 0.1)

The significant reduction in AST levels (MD = −6.72 U/L; P = .009), along with a strong trend toward ALT reduction (MD = −10.75 U/L; P = .06), supports improvements in hepatic inflammation.

also in 5,725 other papers

a favorable trendno p-value reported

The observed reduction in serum cholesterol, although not statistically significant in this analysis ( P = .23), follows a favorable trend and is consistent with the known lipid-modifying effects of GLP-1 RAs.

also in 1,335 other papers

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