Psychometric Evaluation of the PRO-CTCAE Average Composite Score: Reliability, Responsiveness, Known-Groups Validity, and Sensitivity to Group Differences.

In head and neck cancer, the direction of the difference was consistent with expectations but did not reach statistical significance (0.90 vs. 1.06; n = 111 vs. n = 28; p = 0.30, Cohen’s d = 0.26 with 95% CI: −0.16–0.67).

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