Indian Society of Critical Care Medicine Guidelines on Evidence-based Recommendations for the Treatment of Carbapenem-resistant Enterobacterales, Carbapenem-resistant <i>Acinetobacter baumannii</i>, and Carbapenem-resistant <i>Pseudomonas aeruginosa</i> in Critically Ill Patients: A GRADE-guided Approach.

Indian J Crit Care Med · 2026 · PMC13407482 · PMID 42523687

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a favorable trendno p-value reported

42 Sulbactam-based regimens demonstrated a higher microbiological cure in most RCTs and a favorable trend in observational studies.

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a numerical trendno p-value reported

31 While neither trial reached statistical significance, both demonstrated a numerical trend toward higher mortality with colistin.

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did not reach statistical significanceno p-value reported

55 In the observational dataset ( n = 1,532), mortality was observed in 189 of 672 patients (28.1%) treated with sulbactam-based regimens vs 301 of 860 patients (35.0%) in the non-sulbactam group, resulting in a pooled (OR: 0.61; 95% CI: 0.34–1.12, p = 0.10), indicating a 39% lower odds of death with sulbactam-based therapy; however, the difference did not reach statistical significance, showing a trend favoring sulbactam-based regimens.

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