Body Composition and Melanoma Outcomes in Patients on Immunotherapy or Targeted Therapy: An Analysis from Canadian Melanoma Research Network.

Curr Oncol · 2026 · PMC13407559 · PMID 42505205

Europe PMC DOI

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near-significantp = 0.01actually significant

For OS, significant or near-significant interactions ( p = 0.01 to 0.064) were observed for BMI and all body composition measures except IMAT, such that in the targeted therapy group, higher BMI, SAT, VAT, SM and SMI were associated with better OS (HRs 0.56 to 0.65), whereas no effect was seen in the immunotherapy group (all HRs near 1).

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