Alzheimer's blood-based biomarkers, incident dementia, and interactions with age, APOE status, and hormone therapy.

A nominally significant interaction of p‐tau217 levels and CEE/MPA versus placebo was observed, although dementia HRs for p‐tau217 in both the CEE/MPA and placebo groups were elevated. 25 The different BBMs associated with risk of MCI/probable dementia for CEE versus CEE/MPA suggest that there are different pathways and mechanisms that lead to dementia and dementia type for women who use estrogen alone versus estrogen plus progestin.

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