High-Resolution Elemental Analysis of Neuromelanin-Containing Organelles in Human Locus Coeruleus.

Moreover, a methodology for quantitative EDX and semi‐quantitative nano‐SIMS data analysis was applied, demonstrating inter and intrapersonal differences of metals, with a positive trend for iron and sulfur (pheomelanin) to age.

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This revealed a clear trend of iron difference among samples, similar to what was obtained from the nano‐SIMS data: samples with higher nano‐SIMS iron signals generally showed higher iron levels in EDX, and vice versa.

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