An electron-density point-cloud framework for robust protein-ligand interaction prediction.

Nat Commun · 2026 · PMC13408660 · PMID 42277055

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a clear trendno p-value reported

In comparison, models such as SIGN, PSICHIC, and DMFF demonstrated a clear trend of increasing prediction error as structural resolution declined, reinforcing the broader applicability and robustness of E-CloudBind in practical deployment scenarios.

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