ST6GAL1 Glycoengineering Rewires Cytokine Signaling and Preserves Metabolic Fitness in CAR-T Cells Under Galectin-3-Mediated Immunosuppression.

In contrast, STAT5A expression was significantly reduced in ST6 CAR-T cells relative to CAR-T cell controls ( Figure 1 d) ( p < 0.05), whereas STAT5B expression showed a downward trend but did not reach statistical significance ( Figure 1 e).

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