UCP1-Dependent Thermogenic Adipose Tissue in Human Disease: Adipose-Centered Mechanisms, Biomarker Limitations, and Translational Perspectives.

Int J Mol Sci · 2026 · PMC13410023 · PMID 42511758

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In a randomized placebo-controlled human trial, daily oral intake of 9 mg capsinoids for 6 weeks increased supraclavicular BAT vascular density and showed a trend toward elevated resting energy expenditure, selectively in subjects with detectable baseline BAT activity [ 117 ].

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