Prognostic and Predictive Role of Circulating Tumor DNA in Locally Advanced Rectal Cancer Managed With Total Neoadjuvant Therapy: A Systematic Review.

It is also notable that in ENSEMBLE‐2, the association between post‐TNT ctDNA status and the decision to pursue NOM versus surgery trended toward but did not reach statistical significance ( p = 0.063), indicating that ctDNA alone was not yet sufficient to drive the organ‐preservation decision in this cohort [ 21 ].

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