Spatially Resolved Free Fatty Acid Profiling Reveals Region- and Age-Dependent Remodeling of Alzheimer's Disease Plaques.

JACS Au · 2026 · PMC13417193 · PMID 42529446

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Within the n-6 elongation cascade, the DGLA-to-AA ratio (20:4/20:3, proxy for FADS1-mediated Δ5-desaturation) was significantly reduced in subcortical regions, including subiculum and thalamus, with a strong trend in hippocampus ( Figure D).

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