Association between changes in estradiol, serotonin, and BDNF and antidepressant response in perimenopausal depression: a retrospective cohort study comparing integrated TCM-acupuncture with SSRIs.

Front Psychiatry · 2026 · PMC13418564 · PMID 42529667

Europe PMC DOI

hedged sentence

0.0320

closest p · 0.6× alpha

0.0320

boldest claim

The sentences

nominally significantP = 0.032actually significant

1.7%), with a nominally significant adjusted OR of 16.62 (95% CI 1.27–217.22; P = 0.032), though this estimate is imprecise due to sparse events and should be interpreted with caution.

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