Acute opioid responses are modulated by dynamic interactions of <i>Oprm1</i> and <i>Fgf12</i>.

A human GWAS of opioid cessation reported linkage to the FGF signaling pathway in which the effect of FGF12 was nominally significant (p=0.0015, odds ratio = 1.24) ( Cox et al., 2020 ).

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Throughout the first 2 hr after injection of morphine (0–135 min bins), we detected a single and highly significant locus on Chr 10 ( Figure 1 ) with peak linkage that extends from about 5.7–8.9 Mb in males and from 8.9 to 9.6 Mb in females, and a maximal –logp score of 10 and higher for males and 9.6 and higher for females ( Figure 2 ) using quantile normalized locomotor data.

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