Consistent with the active-site directed activity of dasatinib, we observed a clear trend towards increased capture of kinases by 4b relative to both 5b and 5c , including previously reported off-targets of dasatinib such as BTK, CSK, LYN and RIPK2 57 – 59 (Fig. 4b,c,e and Supplementary Tables 7 and 8 ).
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Small-molecule binding-site discovery using silyl ether-enabled chemoproteomics.
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