Enantioselective Synthesis of Axially Chiral Diaryl Ethers via Rhodium-Catalyzed [2 + 2 + 2] Cycloaddition.

Angew Chem Int Ed Engl · 2026 · PMC13427224 · PMID 42233519

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a clear trendno p-value reported

Variation of one ortho substituent on the diaryl ether revealed a clear trend in the activation barriers: methoxy ( 3ab , 30.1 kcal/mol) < methyl ( 3aa , 32.9 kcal/mol) < 4‐methylphenyl ( 3ac , 35.2 kcal/mol).

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