A clear trend emerged across 1a–d , wherein elongation of linear alkyl chains led to improved lithium affinity, with strong correlation between K a and experimentally determined log P ( r 2 = 0.84) [ 55 ], likely due to enhanced hydrophobic interactions and improved preorganization of the binding cavity.
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Rediscovering Sodium Ionophores as Selective Agents for Lithium Recognition and Extraction.
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