Multi-omics Mendelian randomization integrating GWAS, eQTL, mQTL and pQTL data prioritizes mitochondrial gene <i>FXN</i> as a hypothesis-generating candidate for nephrolithiasis.

Although the SMR analysis for mitochondrial gene expression yielded an FDR-corrected p-value (0.050443) marginally above the significance threshold ( Data Sheet - Supplementary Table 5 ), the nominally significant SMR p-value ( P SMR = 1.74×10 -3 ) in conjunction with a non-significant HEIDI test (HEIDI > 0.05) supports a suggestive association between FXN gene expression and nephrolithiasis.

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The resulting network, generated with an interaction confidence score threshold of 0.4 and exhibiting a highly significant PPI enrichment p-value (< 1.0 × 10 -16 ), revealed key functional modules.

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