a decreasing trendp = 0.056
Before FDR correction, glutamate and leucine were significantly lower in advanced stages ( p = 0.045), and lactate showed a decreasing trend ( p = 0.056).
Before FDR correction, glutamate and leucine were significantly lower in advanced stages ( p = 0.045), and lactate showed a decreasing trend ( p = 0.056).
The loss of significance for several nominally significant metabolites after FDR correction may reflect Type II error rather than a particular absence of differences.