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A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis.

Arthritis Rheumatol · 2026 · PMC13430129 · PMID 41711532

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nominally significantno p-value reported
Among these nominally significant metabolites, leukotriene B4 was the most markedly elevated (2.8‐fold) (Figure 2C ) in the recurrent flare group; the amino acids creatine, sarcosine, and L‐canavanine were moderately elevated; and the most markedly decreased metabolites were lipids and lipid‐like molecules.

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