Variant-Specific Landscape of Mutual Exclusivity Among BRAF, EGFR, and KRAS Oncogenes Reveals Overlap With Functionally Antagonistic Mutant Pairs.

Int J Cancer · 2026 · PMC13432369 · PMID 42253180

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a strong trendno p-value reported

In the EGFR∩KRAS and EGFR∩BRAF comparisons, the Classical‐like variants EGFR E746_A750del and EGFR L858R showed a strong trend toward mutual exclusivity with Hydrolysis‐class KRAS G12V/D/C variants, and EGFR L858R was significantly mutually exclusive with class I BRAF V600E .

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