26 Of prospective trials using dopamine agonists (DA) to treat apathy in PD, some showed a benefit (rotigotine 16 mg daily, 27 piribedil 28 ) whereas others have shown trends toward improvement but failed to reach statistical significance, 29 , 30 often in the setting of large placebo effects on apathy.
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Do we need drugs for psychiatric symptoms specifically for Parkinson's disease?
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