Effectiveness and safety of interleukin 6 receptor inhibitors versus conventional immunomodulatory therapy in steroid-refractory polymyalgia rheumatica.

There was a significant trend over the 1-year follow-up period showing that GC dose reduction was greater in the IL-6Ri-treated patients compared with csIM-treated patients (p=0.016).

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Weighted linear regression was used to evaluate the potential for a difference in GC dose reduction in the IL-6 initiators relative to the csIM initiators in 90-day intervals, calculating weights based on the inverse of the width of the 95% CI, as well as assessing for a statistical trend across the four 90-day intervals.

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