Weight mitigation and tolerability of adjunctive topiramate in acute pediatric psychiatry: a retrospective real-world analysis.

Front Psychiatry · 2026 · PMC13439229 · PMID 42558898

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hedged sentences

0.0010

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp < 0.001actually significant

However, a highly significant difference was observed regarding the use of additional mood stabilizers (p < 0.001).

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a negative trendno p-value reported

Dose-response relationship in topiramate users In a dose-response multiple regression analysis conducted exclusively within the topiramate subgroup (n = 45), a negative trend was observed between the topiramate dose and weight change (= -0.014), indicating increased weight loss with higher doses ( Table 7 ).

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