nominally significantP < 0.05
Lastly, we summarized available corresponding observational evidence for identified associations between IDPs and pain-related phenotypes. LDSC regression analysis We used LDSC to evaluate the genetic correlations between 587 structural IDPs and 13 pain-related phenotypes, of which 559 IDP–pain pairs displayed nominally significant genetic correlations ( P < 0.05) ( Figure 2 ).