Digital pharmacoepidemiology of angiotensin-converting enzyme inhibitors in Russia.

At the same time, a positive trend was observed for the INN of enalapril (τ = 0.271 (95% CI 0.140–0.400), p < 0.001), which may reflect a shift among users from searching for specific brands to searching by active ingredient ( Figure 3 ). 3.3 Variability of search interest Time series analysis ( Table 3 ) revealed significant differences in the variability of search interest among the drugs.

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For perindopril, seasonal variations did not reach statistical significance in the analysis of the original time series (χ 2 = 5.52, p > 0.05); however, after removing the upward trend (τ = 0.762), seasonality became highly significant (χ 2 = 68.9, p < 0.001), indicating a masking effect of the trend.

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In particular, a negative trend was identified for the drug “Enap” (τ = −0.171 (95% CI -0.306 to −0.0235), p = 0.022).

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