Evaluating a Genome-Wide Polygenic Score for Handgrip Strength and Its Interplay with Leisure-Time Physical Activity Across the IGEMS Twin Cohorts.

In sex-stratified analyses, the interaction was nominally significant among females (β = −0.043, SE = 0.020, P interaction = 0.035, N = 2013), but did not remain significant after FDR correction (Supplemental Table 8, Supplemental Digital Content, https://links.lww.com/MSS/D409 ); this finding was consistent with the sensitivity analysis adjusting for height (Supplemental Table 9, Supplemental Digital Content, https://links.lww.com/MSS/D409 ).

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