Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study.

PLoS Med · 2006 · PMC1370920 · PMID 16475872

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borderline significantno p-value reported

There was a borderline significant association for incident vertebral fractures under a co-dominant model ( Figure 2 C) particularly in females, where there was a 33% increase in the odds of fracture per allele (OR 1.33 [CI, 1.00 to 1.77], p = 0.05).

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nominally significantno p-value reported

There was no association with fracture overall (odds ratio [OR] = 1.01 [CI, 0.95 to 1.08]) in either unadjusted or adjusted analyses, but there was a non-significant trend for association with vertebral fracture and a nominally significant association with incident vertebral fractures in females (OR = 1.33 [CI, 1.00 to 1.77]) that was independent of BMD, and unaltered in adjusted analyses.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.