Evidence for conservation and selection of upstream open reading frames suggests probable encoding of bioactive peptides.

BMC Genomics · 2006 · PMC1402274 · PMID 16438715

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a strong trendno p-value reported

While this is still lower than is observed for the main coding region AUGs, it is a strong trend and one not observed in the downstream controls, where conserved ORFs have no noticeable enrichment for optimal AUG context.

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