Orchiectomy or androgen receptor blockade attenuates baroreflex-mediated bradycardia in conscious rats.

Although the reduction elicited by the 2 lower doses of flutamide did not reach statistical significance, (5 mg kg -1 : -1.57 ± 0.23, and 15 mg kg -1 : -1.48 ± 0.21 vs. vehicle: -1.97 ± 0.27 beats min -1 mmHg -1 , P > 0.05; Figure 4 ), a significant inverse correlation (r = -0.4, P < 0.05, Figure 5 ) was observed between baroreflex bradycardia and all doses of flutamide.

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