Smad4-expression is decreased in breast cancer tissues: a retrospective study.

Stratifying the collective with regard to the WHO stage not only showed a trend for longer survival in the group of Smad4 negative patients compared to Smad4 positive patients, but also revealed that this effect became most prominent, though still not statistically significant, at WHO stage III patients that already have positive lymph nodes but no distant metastasis (Table 2 ).

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