Hormone replacement therapy and false positive recall in the Million Women Study: patterns of use, hormonal constituents and consistency of effect.

This was mainly because the relative risk (95% CI) of false positive recall among current users of tibolone was 0.76 (0.52–1.10) compared to women who had never used HRT, and the difference in the relative risk of false positive recall between women currently using oestrogen-only, oestrogen-progestagen and tibolone was highly significant (χ 2 2 (heterogeneity) = 21.0, p < 0.0001).

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There was a significant trend in recall according to time since stopping use of HRT (χ 2 1 (trend) = 14.0, p < 0.001), suggesting the wearing off of the effect of HRT over time in past users [ 3 ].

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