The design of transcription-factor binding sites is affected by combinatorial regulation.

Genes involved in metabolism appear to have a higher number of binding sites, but this enrichment is only marginally significant ( P values shown are the probability for a set of this size to have the observed average number of binding sites). 'Preferential attachment' pattern for the addition of new binding sites Our findings are consistent with a model whereby increased fuzziness and increased number of binding sites both reflect reduced selection pressure to maintain precise expression.

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