No role for estrogen receptor 1 gene intron 1 Pvu II and exon 4 C325G polymorphisms in migraine susceptibility.

BMC Med Genet · 2006 · PMC1431511 · PMID 16504171

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an interesting trendno p-value reported

Although our results did not demonstrate this, there was an interesting trend in the female subgroup which we believe warrants further investigation in a larger study group.

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did not reach statistical significanceno p-value reported

While this analysis did not reach statistical significance due to small numbers in the male subgroup, it may warrant further investigation in a larger study group, particularly in view of the previously reported role of the CC genotype in increased stroke risk in males [ 20 ] and the potential relationship between migraine and stroke [ 21 , 32 - 35 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.