Linear response of mutans streptococci to increasing frequency of xylitol chewing gum use: a randomized controlled trial [ISRCTN43479664].

BMC Oral Health · 2006 · PMC1482697 · PMID 16556326

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did not reach statistical significanceno p-value reported

For the smallest dose of 3.44 g/day, a reduction was observed but did not reach statistical significance.

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highly significantno p-value reported

This knowledge is highly significant in considering the feasibility of public health prevention programs using xylitol.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.