Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema.

Although the increase in the expression of the three slower adult isoforms did not reach statistical significance for any individual isoform, all demonstrated a trend to greater expression in emphysema.

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Because there was very little difference in body mass between control and emphysematous animals (613 ± 15 g control, n = 11; 629 ± 11 g emphysema, n = 9; P = 0.42), the differences in lung volume were highly significant whether or not they were normalized to body mass.

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