Human CD81 directly enhances Th1 and Th2 cell activation, but preferentially induces proliferation of Th2 cells upon long-term stimulation.

BMC Immunol · 2003 · PMC151668 · PMID 12597781

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difference was apparentno p-value reported

The difference was apparent after one day of stimulation, and did not increase over time, consistent with a greater initial induction of proliferation of IL-4-producing cells in the presence of anti-CD81.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.