An infection in the genital tract was probably responsible for the deaths of 26/35 control, 14/32 low- dose, and 8/20 high-dose female mice before the end of the study. Acinar-cell adenomas in the pancreas of male rats occurred with a positive trend (P < 0.01), and the incidence in the high-dose group (37/49, 76%) was significantly (P<0.01) higher than in the vehicle controls (22/50,40%).
19/50) in high dose female mice. The incidence of hepatocellular carcinomas (vehicle con- trol, 10/50; high dose, 19/50) was significantly increased in high dose male mice, although the combined incidence of hepatocellular adenomas or carcinomas (vehicle con- trol, 23/50; high dose, 27/50) was marginally significant by the life table test but not by the incidental tumor test.
The survival of male mice was also low (16/50; 16/50; 19/50), but there was a significant trend toward increased survival of dosed female mice relative to that of the vehicle controls (26/50; 35/50; 34/50).