Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers.

Highly significant differences were found in serum levels of VEGF between SSc patients and healthy controls, whereas no differences could be detected for endostatin and basic fibroblast growth factor.

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Patients with limited SSc showed less clear differences, which did not reach statistical significance, when analyzed according to the presence of fingertip ulcers (limited SSc without fingertip ulcers: n = 13; median, 332 pg/ml; range, 185–826 pg/ml; limited SSc with fingertip ulcers: n = 7; median, 187 pg/ml; range, 135–663 pg/ml) ( P = 0.36).

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