Exogenous pulmonary surfactant for the treatment of adult patients with acute respiratory distress syndrome: results of a meta-analysis.

Crit Care · 2006 · PMC1550886 · PMID 16542488

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did not reach statistical significanceno p-value reported

Although there was a trend to improved oxygenation, this did not reach statistical significance (mean change 13.18 mmHg, standard error 8.23 mmHg; 95% CI -2.95, 29.32).

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may be significantno p-value reported

The timing of administration is an important issue as the response to early therapy versus delayed therapy may be significant [ 3 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.