Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone.

Similarly, there was a trend toward increased metastasis of 66cl4beta3 tumors to the lung compared with 66cl4pBabe tumors, with average relative tumor burdens of 590 ± 303 and 295 ± 163 (mean ± standard error of the mean), although the difference did not reach statistical significance ( P = 0.32) – most probably due to the stochastic nature of spontaneous metastasis (Figure 2f ).

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