Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors.

In fact, we did not see a significant enrichment of cluster B genes within the top tumor ERα correlates, though a trend towards significance was evident ( p = 0.12, Figure 2b ).

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As we tested about 22,000 genes for significance of expression, many genes may give a nominally significant p value by chance alone.

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To determine the physiological relevance of these genes, we compared them with genes showing E2-regulation in vivo in xenograft tumors, observing a highly significant number of the same genes being regulated by E2 in vivo as well as in vitro .

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