Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study.

There was a nominally significant association between AAA and HLA-DQA1 locus in the Belgian population (empirical p = 0.039; asymptotic p = 0.049; p = 0.147 after Sidak correction for multiple testing).

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In haplotype analyses, marginally significant association was found between AAA and haplotype HLA-DQA1-DRB1 (p = 0.049 with global score statistics and p = 0.002 with haplotype-specific score statistics).

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The p-values were: 0.062 (empirical: 0.056) for DQA; 0 (empirical: 0.0001) for DQB, 0.008 (empirical: 0.0046) for DRB, and 0 (empirical: 0.0001) for DRB3-5; and 2) in our previous work we showed highly significant departure from Hardy-Weinberg proportions for several markers in the combined sample, but not in the subsets, indicating evidence for the presence of population stratification [ 31 ].

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