Stratification of non-small cell lung cancer patients for therapy with epidermal growth factor receptor inhibitors: the EGFR fluorescence in situ hybridization assay.

Interestingly, if the EGFR genomic abundance in tumors is evaluated by other techniques, such as Southern Blotting or quantitative real-time PCR, the association between increased gene copy numbers and sensitivity to TKI is non-significant or marginally significant (30,35,36).

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Nevertheless, there was a clear trend towards better outcome in the treated group of patients comparing to placebo, suggesting that there is a subset of patients who benefit from using gefitinib.

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